Monday, October 21, 2013

Obama: 'No excuse' for health care signup problems


WASHINGTON (AP) — President Barack Obama on Monday offered "no excuses" — and little explanation — for the computer bugs still frustrating Americans who are trying to enroll online for insurance plans at the center of his health care law. But software developers tasked with building the site said they saw signs a year ago that the debut could fail.

One source of the troubles appears to be the testing procedures employed before the rollout three weeks ago. Several developers of the HealthCare.gov website told The Associated Press they were worried for months about the system's readiness and whether the software meant to link key computer systems was being properly put through its paces.

In addition, congressional investigators raised concerns before the rollout that the Centers for Medicare and Medicaid Services had taken on the job of testing the computer systems for the new markets during the final weeks before the sign-ups opened Oct. 1. That job is often handled by specialized software companies.

Obama, who emphasized the website's simplicity in the week's leading up to the insurance sign-ups, admitted there could now be "no sugarcoating" the problems even as he talked up the benefits of the law at a Rose Garden event that had the feel of a pep rally.

"The website that's supposed to make it easy to apply for and purchase the insurance is not working the way it should for everybody," he said.

He insisted that the problems would be fixed and all Americans seeking insurance would be able to sign up. But it was not clear how quickly that would happen. The administration is beefing up call centers and encouraging more people to enroll over the phone while the website problems persist.

The flood of computer problems since the website went online has been deeply embarrassing for the White House. The glitches have called into question whether the administration is capable of implementing the complex policy and why senior White House officials — including the president — appear to have been unaware of the scope of the problems when the health insurance markets, known as exchanges, opened.

Obama stopped short of apologizing for the failures, saying instead that "nobody is more frustrated than me."

Even as he spoke, more problems came to light. The administration acknowledged that a planned upgrade to the website had been postponed indefinitely and that online Spanish-language signups would remain unavailable, despite a promise to Hispanic groups that the capability would start this week.

The White House says additional technology experts from both inside and outside the government are being brought in to work on the failures.

Administration officials initially blamed heavy website traffic for the frozen computer screens that many people encountered when they first logged on. Since then, they have also acknowledged shortcomings with software and some elements of the system's design, although the administration has yet to fully detail exactly what went wrong with the online system and who was responsible for the problems.

It appears the problems were well-known to some of those designing the system. One developer said that in the weeks leading up to the Oct. 1 launch, he and his colleagues huddled in conference rooms trying to patch deficiencies in computer code.

"It was an extremely tight deadline," said the developer, who spoke on condition of anonymity because he was told not to talk to the news media about his work.

A review of internal structural diagrams obtained by AP also revealed the complexity of the system. The diagrams show that applicants must submit at least 50 pieces of personal information, including income and immigration status. That data is then connected to at least eight distinct federal computer systems, including the Social Security Administration and the Peace Corps.

The schematics from late 2012 show how officials preferred a "data services hub" — a traffic cop of sorts for managing information — instead of a setup that would have allowed state exchanges to connect directly to government servers when verifying an applicant's information.

On Sunday, the Department of Health and Human Services said the data hub was working, but the initial consumer experience had not lived up to the public's expectations. "We are committed to doing better."

Administration officials have so far refused to say how many people have actually managed to enroll in insurance during the three weeks since the new marketplaces became available. Without enrollment numbers, it's impossible to know whether the program is on track to reach the projections from the Congressional Budget Office, which estimated 7 million people would gain coverage during the first year the exchanges were available.

Officials have instead pointed selectively to figures putting the insurance exchanges in a positive light. They say more than 19 million people have logged on to the federal website and nearly 500,000 have filled out applications for insurance through both the federal and state-run sites. The applications must be completed before people can enroll in insurance policies.

An internal memo obtained by the AP showed that the administration had projected nearly a half million people would actually enroll for the insurance markets during the first month.

Uninsured Americans have until about mid-February to sign up for coverage if they are to meet the law's requirement that they be insured by the end of March. If they don't, they will face a penalty.

Officials say that at this point they are not considering extending the enrollment window beyond that time. They also say they are not considering taking the website down for an extended time to address the problems, but instead will do that maintenance during low-traffic overnight hours.

But the White House appeared to open the door to not penalizing those whose efforts to sign up were confounded by the system's problems.

"The law is clear that if you do not have access to affordable health insurance, then you will not be asked to pay a penalty because you haven't purchased affordable health insurance," White House spokesman Jay Carney said.

So far, no one within the administration is known to have been fired for the problematic rollout. Some Republicans have focused their ire on Health and Human Services Secretary Kathleen Sebelius, though the White House says she continues to have the confidence of the president.

Sebelius is scheduled to testify about the botched rollout before the House Energy and Commerce Committee next week. Representatives from some of the contractors working on the websites were also scheduled to testify before the committee on Thursday.

___

Associated Press writers Ricardo Alonso-Zaldivar, Luis Alonso and Laurie Kellman contributed to this report.

___

Follow Julie Pace on Twitter at http://twitter.com/jpaceDC and Jack Gillum at http://twitter.com/jackgillum

Source: http://news.yahoo.com/obama-no-excuse-health-care-signup-problems-155553975--politics.html
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gdgt's best deals for October 21st: MakerBot Replicator 2, Nikon D800

Ready to save some cash on your tech buys? Then you've come to the right place. Our friends at sister site gdgt track price drops on thousands of products every day, and twice a week they feature some of the best deals they've found right here. But act fast! Many of these are limited-time offers, ...


Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/0ZobE2AoPRA/
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Nanotech system, cellular heating may improve treatment of ovarian cancer

Nanotech system, cellular heating may improve treatment of ovarian cancer


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PUBLIC RELEASE DATE:

17-Oct-2013



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Contact: Oleh Taratula
oleh.taratula@oregonstate.edu
541-737-5785
Oregon State University






CORVALLIS, Ore. The combination of heat, chemotherapeutic drugs and an innovative delivery system based on nanotechnology may significantly improve the treatment of ovarian cancer while reducing side effects from toxic drugs, researchers at Oregon State University report in a new study.


The findings, so far done only in a laboratory setting, show that this one-two punch of mild hyperthermia and chemotherapy can kill 95 percent of ovarian cancer cells, and scientists say they expect to improve on those results in continued research.


The work is important, they say, because ovarian cancer one of the leading causes of cancer-related deaths in women often develops resistance to chemotherapeutic drugs if it returns after an initial remission. It kills more than 150,000 women around the world every year.


"Ovarian cancer is rarely detected early, and because of that chemotherapy is often needed in addition to surgery," said Oleh Taratula, an assistant professor in the OSU College of Pharmacy. "It's essential for the chemotherapy to be as effective as possible the first time it's used, and we believe this new approach should help with that."


It's known that elevated temperatures can help kill cancer cells, but heating just the cancer cells is problematic. The new system incorporates the use of iron oxide nanoparticles that can be coated with a cancer-killing drug and then heated once they are imbedded in the cancer cell.


Other features have also been developed to optimize the new system, in an unusual collaboration between engineers, material science experts and pharmaceutical researchers.


A peptide is used that helps guide the nanoparticle specifically to cancer cells, and the nanoparticle is just the right size neither too big nor too small so the immune system will not reject it. A special polyethylene glycol coating further adds to the "stealth" effect of the nanoparticles and keeps them from clumping up. And the interaction between the cancer drug and a polymer on the nanoparticles gets weaker in the acidic environment of cancer cells, aiding release of the drug at the right place.


"The hyperthermia, or heating of cells, is done by subjecting the magnetic nanoparticles to an oscillating, or alternating magnetic field," said Pallavi Dhagat, an associate professor in the OSU School of Electrical Engineering and Computer Science, and co-author on the study. "The nanoparticles absorb energy from the oscillating field and heat up."


The result, in laboratory tests with ovarian cancer cells, was that a modest dose of the chemotherapeutic drug, combined with heating the cells to about 104 degrees, killed almost all the cells and was far more effective than either the drug or heat treatment would have been by itself.


Doxorubicin, the cancer drug, by itself at the level used in these experiments would leave about 70 percent of the cancer cells alive. With the new approach, only 5 percent were still viable.


The work was published in the International Journal of Pharmaceutics, as a collaboration of researchers in the OSU College of Pharmacy, College of Engineering, and Ocean NanoTech of Springdale, Ark. It was supported by the Medical Research Foundation of Oregon, the PhRMA Foundation and the OSU College of Pharmacy.


"I'm very excited about this delivery system," Taratula said. "Cancer is always difficult to treat, and this should allow us to use lower levels of the toxic chemotherapeutic drugs, minimize side effects and the development of drug resistance, and still improve the efficacy of the treatment. We're not trying to kill the cell with heat, but using it to improve the function of the drug."


Iron oxide particles had been used before in some medical treatments, researchers said, but not with the complete system developed at OSU. Animal tests, and ultimately human trials, will be necessary before the new system is available for use.


Drug delivery systems such as this may later be applied to other forms of cancer, such as prostate or pancreatic cancer, to help improve the efficacy of chemotherapy in those conditions, Taratula said.


###


Editor's Notes: A graphic to illustrate this drug delivery system is available online: http://bit.ly/15omJcP


The study this story is based on is available online: http://bit.ly/18PLoY4




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Nanotech system, cellular heating may improve treatment of ovarian cancer


[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:

17-Oct-2013



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]


Share Share

Contact: Oleh Taratula
oleh.taratula@oregonstate.edu
541-737-5785
Oregon State University






CORVALLIS, Ore. The combination of heat, chemotherapeutic drugs and an innovative delivery system based on nanotechnology may significantly improve the treatment of ovarian cancer while reducing side effects from toxic drugs, researchers at Oregon State University report in a new study.


The findings, so far done only in a laboratory setting, show that this one-two punch of mild hyperthermia and chemotherapy can kill 95 percent of ovarian cancer cells, and scientists say they expect to improve on those results in continued research.


The work is important, they say, because ovarian cancer one of the leading causes of cancer-related deaths in women often develops resistance to chemotherapeutic drugs if it returns after an initial remission. It kills more than 150,000 women around the world every year.


"Ovarian cancer is rarely detected early, and because of that chemotherapy is often needed in addition to surgery," said Oleh Taratula, an assistant professor in the OSU College of Pharmacy. "It's essential for the chemotherapy to be as effective as possible the first time it's used, and we believe this new approach should help with that."


It's known that elevated temperatures can help kill cancer cells, but heating just the cancer cells is problematic. The new system incorporates the use of iron oxide nanoparticles that can be coated with a cancer-killing drug and then heated once they are imbedded in the cancer cell.


Other features have also been developed to optimize the new system, in an unusual collaboration between engineers, material science experts and pharmaceutical researchers.


A peptide is used that helps guide the nanoparticle specifically to cancer cells, and the nanoparticle is just the right size neither too big nor too small so the immune system will not reject it. A special polyethylene glycol coating further adds to the "stealth" effect of the nanoparticles and keeps them from clumping up. And the interaction between the cancer drug and a polymer on the nanoparticles gets weaker in the acidic environment of cancer cells, aiding release of the drug at the right place.


"The hyperthermia, or heating of cells, is done by subjecting the magnetic nanoparticles to an oscillating, or alternating magnetic field," said Pallavi Dhagat, an associate professor in the OSU School of Electrical Engineering and Computer Science, and co-author on the study. "The nanoparticles absorb energy from the oscillating field and heat up."


The result, in laboratory tests with ovarian cancer cells, was that a modest dose of the chemotherapeutic drug, combined with heating the cells to about 104 degrees, killed almost all the cells and was far more effective than either the drug or heat treatment would have been by itself.


Doxorubicin, the cancer drug, by itself at the level used in these experiments would leave about 70 percent of the cancer cells alive. With the new approach, only 5 percent were still viable.


The work was published in the International Journal of Pharmaceutics, as a collaboration of researchers in the OSU College of Pharmacy, College of Engineering, and Ocean NanoTech of Springdale, Ark. It was supported by the Medical Research Foundation of Oregon, the PhRMA Foundation and the OSU College of Pharmacy.


"I'm very excited about this delivery system," Taratula said. "Cancer is always difficult to treat, and this should allow us to use lower levels of the toxic chemotherapeutic drugs, minimize side effects and the development of drug resistance, and still improve the efficacy of the treatment. We're not trying to kill the cell with heat, but using it to improve the function of the drug."


Iron oxide particles had been used before in some medical treatments, researchers said, but not with the complete system developed at OSU. Animal tests, and ultimately human trials, will be necessary before the new system is available for use.


Drug delivery systems such as this may later be applied to other forms of cancer, such as prostate or pancreatic cancer, to help improve the efficacy of chemotherapy in those conditions, Taratula said.


###


Editor's Notes: A graphic to illustrate this drug delivery system is available online: http://bit.ly/15omJcP


The study this story is based on is available online: http://bit.ly/18PLoY4




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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.




Source: http://www.eurekalert.org/pub_releases/2013-10/osu-nsc101713.php
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Asia stocks gain on US earnings, Europe ebbs


BEIJING (AP) — Asian stocks rose Monday after U.S. markets gained on stronger corporate profits and China reported a rebound in economic growth in the latest quarter. European markets ebbed.

Oil stayed above $100 after briefly dipping below that level last week for the first time in three months.

Tokyo's Nikkei 225 index rose 0.9 percent to 14,693.57 and China's benchmark Shanghai Composite Index added 1.6 percent to 2,229.24. Hong Kong, Seoul and Sydney also rose.

Those gains came after U.S. stocks rose Friday on unexpectedly strong profits from General Electric Co., Morgan Stanley and other companies. Google surged nearly 14 percent, topping $1,000 a share for the first time.

Investors appeared to put behind them concern over U.S. government finances after political leaders agreed to end a 16-day partial shutdown of official services. Congress agreed Wednesday to fund the government and allow it to borrow through early next year.

"Markets are doing nicely today," said strategist Chris Weston of Australia's IG Markets in a report.

Futures augured slight gains on Wall Street. Dow futures rose 0.1 percent to 15,334 and S&P 500 futures added 0.1 percent to 1,737.70.

Early in Europe, France's CAC-40 shed 0.2 percent to 4,277.04 and Germany's DAX lost 0.1 percent to 8,852.16. Britain's FTSE 100 was little changed at 6,624.94.

In Asia, Hong Kong's Hang Seng was up 0.2 percent to 23,379.80. Seoul gained fractionally to 2,053.1 and Sydney's S&P/ASX 200 rose 0.6 percent to 5,351.80. New Zealand, Singapore and Jakarta also gained.

Investors were also encouraged by China's report Friday that economic growth accelerated to 7.8 percent in the three months ended in September, up from the previous quarter's 7.5 percent.

That was despite warnings by some analysts that other indicators show China's recovery, supported by government spending, might already be running out of steam.

"We expect headwinds on economic growth to strengthen," said Morgan Stanley in a report.

"Growth momentum in domestic demand could ease further," it said. "The lower-than-expected export growth is pointing to a bumpy and fragile external demand recovery."

In currencies, the dollar gained 0.4 percent to 98.04 yen. The euro shed 0.1 percent to $1.3669.

Benchmark crude for November delivery was down 39 cents to $100.42 in electronic trading on the New York Mercantile Exchange. The contract added 14 cents on Friday to close at $100.81.

Source: http://news.yahoo.com/asia-stocks-gain-us-earnings-europe-ebbs-081528603--finance.html
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U.S. Senate passes 11th-hour deal to end debt crisis (reuters)

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Reese Witherspoon: Family Fun in Santa Monica

Enjoying a leisurely Saturday with her family, Reese Witherspoon and Jim Toth took the kids to lunch at The Ivy in Santa Monica, California (October 19).


The "Legally Blonde" star wore a navy blue top and a matching short skirt while her mini-me daughter Ava carried baby Tennessee with Deacon close behind.


In the November issue of Elle magazine, the 37-year-old actress opens up about how having children has changed her.


During the interview, Reese shared, "Somebody was saying to me the other day, 'Oh, people get less interesting when they have kids.' I just don't think that's true. I feel like I was so confused before I had kids, I almost got in my own way. Having kids made me clearer about who I was as a woman. I just wanted to exhibit good qualities for my daughter. I was a little competitive before I had kids - probably really competitive, to be honest. It really made me let go of that."


Source: http://celebrity-gossip.net/reese-witherspoon/reese-witherspoon-1039049
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Sunday, October 20, 2013

Kim Kardashian Credits Atkins For Making Her Look Like a Porn Star Again




By Lex October 15, 2013 @ 2:52 PM



Kim Kardashian Visits Her Store DASH In West Hollywood
Nobody wants to pay a Fat Kim Kardashian. Fat Jessica Simpson may still be making a few hundred million selling her discount retail junk, but no Arab prince is going to hand over six rubies to jizz in the eye of a Fat Kim Kardashian. So Kim started the Atkins diet as soon as doctors told her it would be medically safe for the staff raising her baby. Kim’s had to learn to restructure her diet away from favorite carbs such as breads and pastas, and more toward fatty proteins like Khloe. It’s worked to the tune of a 25-lb. drop for the merchandising whore. With just 15-lb to go to reach her target weight of platinum rapper ass-tap worthy, Kim seems right on track with her career and covering up looks of surprise when people remind her she has a kid.


Photo Credit: FameFlynet, INFphoto.com, WENN






Source: http://www.wwtdd.com/2013/10/kim-kardashian-credits-atkins-for-making-her-look-like-a-porn-star-again/
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